How CBD affects the liver? 

Juliet D'cruz

Updated on:


A study conducted to find the effects of CBD on liver disease found that CBD could halt the progress of cirrhosis. Also, it was shown to reduce inflammation and fibrosis in mice, with no side effects. In addition, CBD has been linked to reducing the development of diabetes, atherosclerosis, and hepatic steatosis (fatty liver). It has also been flagged as beneficial in the treatment of schizophrenia, multiple sclerosis, and epilepsy.

CBD and Liver Damage 

Detoxifies the body

A recent study has shown that CBD may damage the liver and its ability to detoxify.

Risk factors for developing liver problems while taking CBD include liver disease, oral contraceptives, HIV/AIDS medications, other prescription medications that may cause increased liver enzymes, acetaminophen-containing medications, alcohol abuse.

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According to the study, CBD reduces liver enzymes which are used as markers for liver damage. This phenomenon probably more likely results from altered metabolism or loss of function rather than some toxic action on hepatocytes. If further studies show significant changes in liver enzymes with long-term use of CBD, it would suggest that patients being treated with a CBD flower have an increased risk of liver damage.

Increased untreated blood sugar level

The liver regulates blood sugar levels by producing glucose from stored glycogen or breaking down fats into glycerol for energy production through gluconeogenesis.

If CBD reduces levels of liver enzymes, this may result in higher untreated blood sugar levels for patients who are taking insulin or oral hypoglycemic drugs that lower blood sugar. Higher levels of these drugs mean that liver enzymes are not being regulated as closely. This could lead to liver damage over time. Before starting CBD treatment, patients should consult their healthcare provider about monitoring their blood sugar levels.

The way the liver responds to cannabinoids may be influenced by genetic factors or altered by other medications or even disease itself “in a sex-specific manner.” This means that the liver metabolism of CBD may vary depending on gender.

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Everything about absorption 

When taken orally, it takes about 45 minutes to an hour before you notice any effects of CBD on your liver function because it has to be processed through the digestive tract first, which slows absorption rates.

This is a reason to start with smaller doses and work up slowly. Also, you might want to slightly increase your CBD and delta 8 dosage if you notice that it takes longer for the effects of CBD on your liver function to be noticeable. Since this process varies from person to person, it’s also best to experiment slowly under the supervision of your healthcare provider.


Despite there being no evidence yet to suggest CBD causes liver damage, the studies indicate that patients who take CBD may have an increased risk of developing liver problems if they have pre-existing liver issues or are taking medications that affect the liver.

Those who take CBD should review their alcohol use and any medications that may affect the liver. In addition, they should consult their healthcare provider before starting CBD treatment to monitor liver enzyme levels and how CBD might affect them.